Activity

Mindfulness-based intervention (MBI) may offer a novel means of preventing excess weight gain in adolescents, theoretically by decreasing stress-eating through altering executive functioning (EF) and food-reward sensitivity.

N=54 12-17y girls and boys at-risk for excess weight gain (i.e., BMI ≥70th percentile or two biological parents with reported obesity [BMI ≥30kg/m

]) participated in a 1.5-year follow-up of a pilot randomized controlled trial comparing 6-week/6-session MBI (n=29) and a health education (HE) control (n=25). Laboratory stress-eating, food-reward sensitivity, EF, perceived stress, and BMI/adiposity were re-assessed at 1.5-years with validated measures. Changes from baseline to 1.5-year follow-up were explored with ANCOVA, accounting for the respective baseline outcome, age, and sex.

Compared to MBI (M=-21, SE=59), HE had greater increases in stress-eating from baseline to 1.5-years (M=194, SE=63, Cohen’s d=0.59, p=.01). There were no other between-condition differences.

MBI may prevent worsening stress-eating for adolescents at-risk for excess weight gain. The potential for MBI as an intervention for stress-eating and ultimately, weight stabilization warrants testing in an adequately-powered trial.

MBI may prevent worsening stress-eating for adolescents at-risk for excess weight gain. The potential for MBI as an intervention for stress-eating and ultimately, weight stabilization warrants testing in an adequately-powered trial.Under typical conditions for dynamic nuclear polarization (DNP)-temperature about 1 K or below and magnetic field about 3 T or higher-the polarization agent causes nuclear dipolar order to relax up to four orders of magnitude faster than nuclear polarization. However, as far as we know, this ultra-fast dipolar relaxation has thus far not been explained in a satisfactory way. We report similar ultra-fast dipolar relaxation of proton spins in naphthalene due to the photo-excited triplet spin of pentacene and propose a three-step mechanism that explains such ultra-fast dipolar relaxation by ground state electron spins as well as by photo-excited triplet spins nuclear spin diffusion transfers nuclear dipolar order-that is nuclear dipolar energy-spatially to near the electron spins. check details Flip-flop transitions between nuclear spins near the electron spins convert this dipolar energy into electron-nuclear interaction energy. Finally electron spin-lattice relaxation or decay of the triplet spin transfers the latter type of energy to the lattice. We will show that this mechanism quantitatively explains the observed dipolar relaxation rate. The proposed mechanism is expected to contribute to dipolar relaxation in any spin system containing more than one spin species. It tends to create a stationary state, in which all dipolar interactions are combined in a single energy reservoir described by a single spin temperature. As an example we suggest that the addition of a relaxation agent in samples used for DNP may significantly accelerate the relaxation of the dipolar energy of the polarization agent, and as a result could possibly reduce the contribution of thermal mixing (TM) to DNP.

Day case unicompartmental knee arthroplasty (UKA) is increasingly being performed worldwide. When performed in the appropriate patient, day case UKA has been demonstrated to be safe, cost effective and improve resource allocation. Limited evidence highlights increased patient satisfaction of day case UKA when compared with inpatient UKA. A detailed study of the patient perspective, experience and satisfaction following day case UKA has not been described before.

A retrospective case series review of 21 consecutive patients (19 unilateral, 2 bilateral) undergoing day case UKA in an elective orthopaedic centre was undertaken. A qualitative and quantitative patient assessment of the day case UKA experience was administered. A five-point Likert scale satisfaction questionnaire, Oxford Knee Score (OKS) and open-ended interview was undertaken. The qualitative responses underwent thematic analysis.

One hundred percent of patients expressed satisfaction (76.2% completely satisfied, 33.8% moderately satisfied) w through a multidisciplinary approach with well-defined clinical pathways for a high-quality patient-centred experience.Parapneumonic effusion (PPE) is a common condition that causes death in patients hospitalized with pneumonia. Rapid distinction of complicated PPE (CPPE) from uncomplicated PPE (UPPE) in Computed Tomography (CT) scans is of great importance for the management and medical treatment of PPE. However, UPPE and CPPE display similar appearances in CT scans, and it is challenging to distinguish CPPE from UPPE via a single 2D CT image, whether attempted by a human expert, or by any of the existing disease classification approaches. 3D convolutional neural networks (CNNs) can utilize the entire 3D volume for classification however, they typically suffer from the intrinsic defect of over-fitting. Therefore, it is important to develop a method that not only overcomes the heavy memory and computational requirements of 3D CNNs, but also leverages the 3D information. In this paper, we propose an uncertainty-guided graph attention network (UG-GAT) that can automatically extract and integrate information from all CT slices ie-of-the-art methods by a large margin. Code is available at https//github.com/iMED-Lab/UG-GAT.Most cardiomyocytes in the left ventricle wall are grouped in aggregates of four to five units that are quasi-parallel to each other. When one or more “cardiomyocyte aggregates” are delimited by two cleavage planes, this defines a “sheetlet” that can be considered as a “work unit” that contributes to the thickening of the wall during the cardiac cycle. In this paper, we introduce the skeleton method to measure the local three-dimensional (3D) orientation of cardiomyocyte aggregates in the sheetlets in three steps data segmentation; extraction of the skeleton of the sheetlets; and calculation of the local orientation of the cardiomyocyte aggregates inside the sheetlets. These data include a series of virtual tissue volumes and five transmural human left ventricle free wall samples, imaged with 3D synchrotron radiation phase-contrast microtomography, and reconstructed with a 3.5×3.5×3.5μm3 voxel size. We computed the local orientation of the cardiomyocyte aggregates inside the sheetlets with a working window of 112×112×112μm3 in size. These data demonstrate that the skeleton method can provide accurate 3D measurements and reliable screening of the 3D evolution of the orientation of cardiomyocyte aggregates within the sheetlets. We showed that in regions that contain one population of quasi-parallel sheetlets, the orientation of the cardiomyocyte aggregates undergo “oscillations” along the perpendicular direction of the sheetlets. In regions that contain two populations of sheetlets with a different angular range, we demonstrate some discontinuity of the helix angle of the cardiomyocyte aggregates at the interface between the two populations.Pagano and collaborators have recently reported lower ventral striatum D3 receptor availability in Parkinson’s disease using PET scan. Our group conducted the first postmortem study of individuals with PD who had ICD and related behaviours in life and reported lower alpha-synuclein pathology and D3R levels in the nucleus accumbens of such individuals. The findings by Pagano and co-authors of low D3R binding in PD patients at baseline, when taken together with our findings of lower Lewy pathology and D3R in the nucleus accumbens, favour the hypothesis that D3R levels are downregulated because of excessive synaptic dopamine.

Different attentional processing of emotional information may underlie social impairments in Autism Spectrum Condition (ASC). It has been hypothesized that individuals with ASC show hypersensitivity to threat, which may be related to an avoidance behaviour. However, research on the attentional processing of emotional information in autism is inconclusive.

To examine the attentional processing biases of 27 children with ASC and 25 typically developed (TD) participants.

The initial orienting of attention, the attentional engagement, and the attentional maintenance to complex emotional scenes in competition (happy, neutral, threatening, sad) were assessed in a 20-second eye-tracking based free-viewing task.

i) children with ASC showed an initial orienting bias towards threatening stimuli; ii) TD children demonstrated an attentional engagement and maintenance bias towards threat, while children with ASC did not; and iii) in children with ASC, attentional problems and somatic complaints were associated with higher initial orienting and with higher attentional maintenance towards threat, respectively.

These results suggest that a perceived threat induces an early overwhelming response in autism, giving rise to an avoidance behaviour. The findings endorse affective information processing theories and shed light on the mechanisms underlying social disturbances in ASC.

These results suggest that a perceived threat induces an early overwhelming response in autism, giving rise to an avoidance behaviour. The findings endorse affective information processing theories and shed light on the mechanisms underlying social disturbances in ASC.The self-organized task switching paradigm enables to investigate the link between task performance and task selection in a voluntary task switching setting that benefits task switches over task repetitions. For example, waiting for a repetition-related stimulus onset denotes environmental costs, which are balanced with internal task-switch costs. Here we extent this research by asking whether movement effort also plays a crucial role for task selection. In detail, we investigate how motor-related consequences, i.e., increasing force for task repetitions, influence task-switching behavior. Participants voluntarily switched between a number (i.e., even or odd) or letter task (i.e., vowel or consonant) using a robot system for response execution. With consecutive task repetitions the robot system was harder to move to the response target as we systematically added a damping load. We found that switch rate correlated with cognitive switch costs (i.e., costs in reaction time, r = -0.741, and error rate, r = -0.54r skills.In the context of the embodied cognition debate, an effect of motion verb associated speed information has previously been detected using eye-tracking, functional magnetic resonance imaging (fMRI), and reaction times (RT). The latter, for instance, was implemented by Wender and Weber (1982), who observed that participants were faster in detecting motion in sentences associated with fast motion compared to sentences associated with slow motion after having formed mental images of the sentences’ content. It remains open whether the reported effects of speed are associated with automatic lexical-semantic retrieval processes or whether they reflect higher top-down cognitive processes. To answer this question, the paradigm by Wender and Weber (1982) was adopted and further elaborated in the present study. In Experiment 1 visualization instructions were eliminated. Additionally, the stimulus material was manipulated in regards to the agent of the described movement (human vs. object motion) in order to determine the representation’s modality (visual vs.