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The PCa patients Gleason score and tumor node metastasis (TNM) positively correlated with promoter methylation level of serum DACT-2. The DACT-2 methylation rate was 0.745 with a sensitivity of 81.8%, and a specificity of 75.0%, the sensitivity, and specificity of PSA was 80.1% and 59.4%. ROC curve results displayed that the diagnostic value of DACT-2 is superior to PSA.

Our study confirms that the level of methylation of the DACT-2 promoter in patients with PCa is much higher than that in patients with benign prostatic hyperplasia (BPH) and healthy subjects, suggesting that DACT-2 methylation in serum is a potential biomarker of PCa.

Our study confirms that the level of methylation of the DACT-2 promoter in patients with PCa is much higher than that in patients with benign prostatic hyperplasia (BPH) and healthy subjects, suggesting that DACT-2 methylation in serum is a potential biomarker of PCa.

Several severity scales have been documented to predict the short-term mortality of septic patients. However, the predictive efficacies of different severity scales in the long-term mortality of the elderly have yet to be evaluated.

In the retrospective study, a cohort of 4,370 elderly (≥65 years) septic patients admitted to the intensive care unit (ICU) were divided into three different age groups, i.e., the younger-old group (65 years ≤ age <75 years), the older-old group (75 years ≤ age <85 years) and the oldest-old group (age ≥85 years). Five scales, including the Simplified Acute Physiology Score II (SAPS II), the Oxford Acute Severity of Illness Score (OASIS), the Modified Logistic Organ Dysfunction System (MLODS), the Systemic Inflammatory Response Syndrome (SIRS) and Sequential Organ Failure Assessment (SOFA), were used for disease severity evaluations. The Kaplan-Meier survival curve, and the area under the receiver operating characteristic curve (AUC) were used to assess prognostic values U.

The prevalence of depression among Chinese college students tends to be higher in recent years, which has caused a series of negative effects in their lives. One of the factors is perfectionism, and few researches have been conducted to examine the role of self-compassion in perfectionism and depression link. The purpose of the study was to explore the relationships between perfectionism, self-compassion, and depression in the context of Chinese undergraduates.

The anonymous self-reported questionnaires including three scales on perfectionism, selfcompassion, and depression were utilized in the study. A total of 540 undergraduates were recruited from three universities in Nanjing and Xi’an by using convenient cluster sampling and were required to complete the questionnaires. Pearson correlation analysis was used to examine the correlation between variables. Multiple linear regression analysis was used to examine the predictive effects of perfectionism and selfcompassion on depression. Hierarchical multiplollege students, and further study is needed to verify this possibility.Acute poisoning could result in hepatic dysfunction which is potentially life threatening. We reviewed three cases of poison-induced liver injury with gastrointestinal disorder on admission. Two cases were poisoned by mushroom α-Amanitin while the other was poisoned by acetaminophen (APAP). They were cured under the close monitor of laboratory examinations and other supportive therapies, as well as the off-label medication of etanercept, a kind of tumor necrosis factor-α (TNF-α) blockers with written informed consent. Among them, case1 was given the first dose doubling of TNF-α blockers for higher liver enzyme levels. There is a lack of effective and safe treatments for poison-induced liver injury. TNF-α has been proved to play an important role in the aggravation of liver injury and the start-up of inflammatory cascade reaction. Therapy with TNF-α blockers shown potential therapeutic efficacy in hepatic dysfunction by some researches. Anyway, no strong recommendation could be drawn from these small sample size studies. On the other side, TNF-α could also mediate an opposing effect for hepatocytes since the hepatic toxicity of TNF-α blockers has generated attentions. The safety for the off-label medication of TNF-α blockers in liver injury, however, still lacks strong evidences. More experimental and clinical researches are needed to focus on potential mechanisms.We have collected the data of five patients with ovarian teratoma and anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis admitted to the Southern Hospital of Southern Medical University from June 2014 to December 2017, we found that all of them started with psychiatric symptoms, four had autonomic nervous system dysfunction, while all of them exposed to abnormal brain and pelvic imaging, four patients required mechanical ventilation to assist breathing during the hospital stay. The serum anti-NMDAR antibodies were positive in five patients. After immunotherapy and surgery, all patients showed favorable prognosis. read more Pathology four mature teratomas and one immature teratoma. In conclusion, patients with ovarian teratoma with anti-NMDAR encephalitis often begins with neurological and psychiatric symptoms, it is easy to be misdiagnosed due to the lack of overt symptoms, while the early detection and tumor resection combined with immunotherapy will win favorable prognosis.Many cases of novel coronavirus 2019 (COVID-19) have confirmed in many countries around the world. Due to the disorders of the immune system, diabetic patients are more likely to suffer from severe COVID-19. Glucagon-like peptide 1 analogues (GLP-1 analogues) commonly can be used to reduce blood sugar. There is no clear evidence that it can be safely and effectively used in patients with diabetes merged severe COVID-19. In this case, we described A 65-year-old male with hypertension and diabetes was diagnosed with severe COVID-19, he took liraglutide at doses ranging from 0.8 to 1.8 mg. Before admission, liraglutide was not used to reduce blood glucose. Hydroxychloroquine sulfate and abidol were used to antivirus and supportive treatment were used simultaneously during hospitalization. During treatment, the patient’s own state was paid attention to, and blood glucose, liver function, kidney function, white blood cells, lymphocytes and other indicators were checked and chest CT was reviewed regularly, which could reflect changes in disease.