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Public health measures to contain the spread of COVID-19 have resulted in adverse effects, including high level of psychological distress, anxiety, and depression.

This study explored adolescent psychopathological profiles at age 17, and their role in predicting the impact of the COVID-19 pandemic at age 19.

The analyses used a sample of 904 participants (mean age=19.17years) from the Millennium Cohort Study (MCS) sweep 7 who completed the mental health questions from January 2018 to March 2019 (mean age=17.18years) and the COVID-19 Survey in May 2020. Adolescent psychopathological profiles were identified by means of latent class analysis.

Four psychopathological profiles were identified “low-symptom class” (60.17% of participants), “high-symptom class” (23.01% of participants), “substance/behavioural addictions class” (12.03% of participants), and “emotion-dysregulation class” (4.79% of participants). Adolescents in the high-symptom and emotional-dysregulation classes had the worst outcome during the lockdown. Specifically, they experienced more stress, conflict and loneliness, and lower levels of perceived social support than adolescents in the other psychopathological classes. Adolescents in the emotional-dysregulation class also consumed more alcohol and had worse financial situation during the lockdown compared to pre- lockdown period.

Adolescent psychopathological profiles predicted mental health impacts of the COVID-19 outbreak.

Adolescent psychopathological profiles predicted mental health impacts of the COVID-19 outbreak.Industrial-scale pharmaceutical applications still face many challenges in overcoming the low absorption and bioavailability of poorly water-soluble drugs. Hot-melt extrusion has emerged as a promising approach with continuous processing on an industrial scale for the preparation of drug delivery systems. Many reviews have mentioned the potential applications, processes, principles and advantages and disadvantages of hot-melt extrusion in the pharmaceutical industry. However, a focus on the recent progress of hot-melt extrusion, which investigates the impacts of processes and formulations of solid dispersions of poorly water-soluble drugs, is missing. In this review, various factors, including polymers, drug properties, additives and surfactants, in solid dispersion SD formulations by hot-melt extrusion will be discussed. Moreover, the effects of the hot-melt extrusion process on the physicochemical properties of solid dispersions will be mentioned. The utilization of molecular interactions in hot-melt extrusion to improve drug stability will also be described. Overall, this summary of recent studies on solid dispersion by hot-melt extrusion will provide perspectives and effectiveness for the development of formulations containing poorly water-soluble drugs.The aim of the study was to determine the stability and complexity of muscle synergies to provide insight to the neural control of gait stability in walking and running and when performing a concurrent cognitive dual task. Eighteen healthy young adults performed walking and running at preferred speeds and 120% of preferred speeds in single and dual task conditions. Muscle synergies were determined from the activity of 9 trunk and leg muscles and centre of mass (COM) motion was recorded with an inertial measurement unit. Local dynamic stability, complexity and width of synergies, and stability and complexity of COM motion were determined, in addition to the cross sample entropy to determine the coupling between COM motion and muscle synergies. Increasing locomotion speed increased complexity and decreased stability of COM motion with a concurrent decrease in synergy complexity and stability but with no change in synergy width. The coupling of COM motion and muscle synergies also increased with increasing speed. Vertical COM motion was more complex and less stable but with no change in anterior-posterior or medio-lateral directions in dual task locomotion. Muscle synergies were also more stable in dual task conditions. These findings indicate that changes in neuromotor dynamics may underpin reported changes in COM local stability during gait as the neural commands responsible for generating the movement are altered in response to increasing task demands. Increased cognitive demands lead to more stable neuromotor commands possibly to maintain local stability of COM motion in the anterior-posterior and medio-lateral directions.Congruent visual information enhances auditory speech perception. This visual benefit has been widely observed in perception of consonants and vowels, and linked to reduced amplitudes and latencies of auditory N1 and P2 event-related potential (ERP) components when visual information was present. However, it remains unclear whether lexical tone perception in Mandarin also shows this visual benefit. This question is theoretically important given the low visual saliency of lexical tones. Nor-NOHA mouse The current study compared the N1/P2 reduction in Mandarin lexical tones and consonants perception with a discrimination task. Result showed amplitude reductions in N1/P2 and a latency reduction in N1 for audiovisual lexical tone perception. These findings suggest that lexical tone perception was also helped by visual information as found in consonants. Furthermore, this visual benefit in N1 for lexical tone perception was delayed relative to consonants.Twins provide a valuable perspective for exploring the pathological mechanism of autism spectrum disorder (ASD). We aim to analyze differences in the topological properties of the white matter (WM) network between monozygotic twins with ASD (MZCo-ASD) and children with typical development (TD). We enrolled 67 subjects aged 2-9 years. Twenty-three pairs of MZCo-ASD and 21 singleton children with TD completed clinical assessments and diffusion tensor imaging (DTI). Graph theory was used to compare the topological properties of the WM network between the two groups, and analyzed their correlations with the severity of clinical symptoms. We found that the global efficiency (Eg) of MZCo-ASD is weaker than that of TD children, while the shortest path length (Lp) of MZCo-ASD is longer than that of TD children, and MZCo-ASD have three unique hubs (the bilateral dorsolateral superior frontal gyrus and right insula). Eg and Lp were both correlated with the repetitive behavior scores of the Autism Diagnostic Interview-Revised (ADI-R) in the MZCo-ASD group, and the nodal efficiency of the dorsal superior frontal gyrus (SFGdor) was correlated with the ADI-R scores of repetitive behaviors.