Bonner Alexander

Varicella-zoster virus (VZV) is a medically important human herpesvirus that causes chickenpox and shingles, but its cell-associated nature has hindered structure studies. Here we report the cryo-electron microscopy structures of purified VZV A-capsid and C-capsid, as well as of the DNA-containing capsid inside the virion. Atomic models derived…[Read more]

OCT angiography (OCT-A) allows non-invasive blood flow registration of the retina and choroid. In contrast to fluorescein angiography (FA), no dye has to be administered. The OCT-A also provides depth-selective information. OCT-A and FA were compared in patients with neovascular age-related macular degeneration (AMD) with retinal angiomatous…[Read more]

Few studies have evaluated the effects of ambient air pollution exposure on lung function, especially in areas with high air pollution levels.

To investigate the associations of annual concentrations of particulate matter with diameters<2.5μm (PM

) and nitrogen dioxide (NO

) with adult lung function in Shanghai, China.

We…[Read more]

Temporal activation of biological processes by visible light and subsequent return to an inactive state in the absence of light is an essential characteristic of photoreceptor cells. Inspired by these phenomena, light-responsive materials are very attractive due to the high spatiotemporal control of light irradiation, with light being able to…[Read more]

004). Of those trained using tactile instruction, 60.3%, with no gender differences, felt it was also important for endoscopic learning. More women reported experiencing gender bias toward themselves during training (57.4% vs 13.1%; P= .001) as well as in their current careers (50.0% vs 9.8%; P= .001). When queried on treatment of…[Read more]

The incidence of esophageal adenocarcinoma (EAC) has been rising dramatically in the past few decades in the United States and Western world. The N-myc downregulated gene 4 (NDRG4) belongs to the human NDRG family. In this study, we aimed to identify the expression levels, regulation, and functions of NDRG4 in EAC. Using an integrative epigenetic…[Read more]

There is a high prevalence of orofacial clefts in low- and middle-income countries with significant unmet need, despite having 50% of the population younger than 18 years in countries such as the Democratic Republic of Congo (DRC). The purpose of this article is to report on the experience of general surgeons with orofacial clefts at a single…[Read more]

Probe-based confocal laser endomicroscopy (pCLE) is a promising imaging tool that provides in situ and in vivo optical imaging to perform real-time pathological assessments. However, due to limited field of view, it is difficult for clinicians to get a full understanding of the scanned tissues. In this paper, we develop a novel mosaicing framework…[Read more]

op IgE-mediated allergy over time to offending foods. In addition, IgE sensitization in FPIAP does not have an unfavorable effect on tolerance development; however, the transition to an IgE-mediated phenotype may delay tolerance for a brief time.

To discuss the skin microbiome modulates immunity by interactions between skin immunology with…[Read more]

Titanium and titanium alloys are widely used in orthopedic implants. Modifying the nanotopography provides a new strategy to improve osseointegration of titanium substrates. Filamentous actin (F-actin) polymerization, as a mechanical loading structure, is generally considered to be involved in cell migration, endocytosis, cell division, and cell…[Read more]

In addition, using quantitative real-time PCR (Q-PCR) and western blot methods, we found that the relative mRNA and protein expression of lal2 in lamprey leukocytes and sera increased significantly at different times after stimulating with Staphylococcus aureus, Vibrio anguillarum, and Polyinosinic-polycytidylic acid (Poly IC). Moreover, LAL2 was…[Read more]

From the results, we found that nano-MOFs have obviously better dispersity, a lower precipitation speed, a smaller standard deviation, ten times higher fluorescence intensities and a much lower LOD than bulk-MOFs. Finally, we draw a conclusion that nano-MOFs are more in line with the requirements of analytical performance as fluorescence sensors,…[Read more]

The use of cemented fixation for hip arthroplasty for femoral neck fractures has been advocated to limit the postoperative and intraoperative risk of periprosthetic fractures. However, there are concerns with the potential effects of cementing on patient mortality, particularly at the time of cementation.

This study examined the mortality…[Read more]

ters. An open-source toolbox has been provided to enable other researchers to readily reproduce and improve upon this work.

The proposed algorithm provides a robust framework for removal of noisy beats and accurate estimation of ICG-based parameters. Importantly, the methodology reduced the ISVar of cardiac parameters. An open-source toolbox…[Read more]

d isavuconazole prophylaxis per protocol. The rate of breakthrough candidemia was 3.1% and there were no invasive mold infections. Our data support the utility of isavuconazole for antifungal prophylaxis after HCT. Peripheral blood stem cells (PBSC) have been increasingly used for allogeneic hematopoietic cell transplantation compared to bone…[Read more]

Dentin remineralization at the bonded interface would protect it from external risk factors, therefore, would enhance the longevity of restoration and combat secondary caries. Dental biofilm, as one of the critical biological factors in caries formation, should not be neglected in the assessment of caries preventive agents. In this work, the…[Read more]

Losing a loved one is among the most common and stressful traumatic events that a child or and adolescent can experience and can be associated with mental health and somatic disorders, as well as a range of life issues and potentially negative outcomes that may impact longitudinal development. Complicated grief, a disorder that has been studied…[Read more]

The investigations revealed multiple external (on the whole body) and internal injuries. According to the statements of those who called the ambulance, the injuries occurred because of falling on the stairs and were considered by the family as being superficial, without requiring medical care. The forensic autopsy, through the external, internal…[Read more]

There is a lack of published data on the clinical response and safety of antibiotics in LLC. Three studies were high risk for bias overall. Further high-quality studies may help determine whether less intensive antibiotic regimens can effectively treat LLC.

The AABB (American Association of Blood Banks) and the College of American Pathologists…[Read more]

In order to investigate the potential of various olive cultivars and leaf sampling times for phytochemical farming practice in Croatia, phenolic and mineral composition was determined in olive leaves of four Croatian cultivars and Italian cultivar Leccino collected at three occasions, in October 2017, January 2018, and March 2018. Istarska bjelica…[Read more]