Conway Singer

To compare the neuropsychiatric symptoms (NPS) of patients with mild cognitive impairment with Lewy bodies (MCI-LB) with those with mild cognitive impairment due to Alzheimer’s disease (MCI-AD).

Subjects with probable MCI-LB (

 = 53), MCI-AD (

 = 60), dementia with Lewy bodies (DLB) (

 = 97) and AD (

 = 202) were recruited.…[Read more]

Increasing ozone concentrations are becoming a severe problem for air pollution in China and have an adverse impact on human health. Here we evaluate premature deaths attributable to long-term exposure to ambient ozone in China between 2013 and 2017 with an air quality model at 5 km resolution and the latest estimates of the relative risk to…[Read more]

Fasciolosis is one of the most important parasitic diseases of livestock. The need for better control strategies gave rise to the identification of various vaccine candidates. The recombinant form of a member of the cysteine protease family, cathepsin L1 of Fasciola hepatica (FhCL1) has been a vaccine target for the past few decades since it has…[Read more]

Research on chronic and acute myeloid leukemia (CML/AML) is focused on the development of novel therapeutic strategies to eliminate leukemic stem/progenitor cells that are responsible for drug resistance and disease relapse. Methods to culture hematopoietic stem/progenitor cells (HSPCs) from blood or bone marrow samples are indispensable for…[Read more]

BACKGROUND Despite the widespread use of sputum weight to assess the effect of airway clearance interventions, its psychometric properties have not been evaluated. The purpose of this ad hoc analysis was to determine the test-retest reliability of 24-h sputum weight in clinically stable individuals with bronchiectasis. This study also aimed to…[Read more]

Organophosphate-chloride complexes [(2,6- i Pr2C6H3-O)2POO2LnCl(CH3OH)4]·2CH3OH, Ln = Nd (1), Eu (2), Gd (3), and Tb (4) have been obtained and structurally characterized. Their reaction with 2,2’6′,2″-terpyridine leads to the formation of 11 adducts ([(2,6- i Pr2C6H3-O)2POO2LnCl(terpy)(H2O)2(CH3OH)], Ln = Eu (5), Gd (6), Tb (7) with exception of…[Read more]

This finding was consistent with binding properties of artesunate-like compounds to mitochondrial proteins and thereby suggested a new mechanistic aspect. Combined, the present study underlines an important role of mitochondria in the multifaceted, host-directed antiviral mechanism of this drug class, postulating a new mitochondria-specific mode…[Read more]

Using autopsy derived lung samples from untreated TB diseased individuals, this report, by applying morphoproteomics, demonstrates that the alveolar macrophages present in the early lesion of TB are primarily of the M2 phenotype. The M2 foamy alveolar macrophages (FAM) are also loaded with MTB antigens by immunohistochemistry and are…[Read more]

1.016-2.191), moderate burnout (OR = 1.852, 95% CI 1.267-2.708), and severe burnout (OR = 2.001, 95% CI 1.145-3.496) were risk factors for MSDs. In conclusion, there is a high annual prevalence of MSDs among the coal mine workers employed in on-site operations in Xinjiang, China. Measures to reduce this prevalence are required.An outbreak of…[Read more]

gsufsort is a fast, portable, and lightweight tool for constructing the suffix array and additional data structures for string collections.

gsufsort is a fast, portable, and lightweight tool for constructing the suffix array and additional data structures for string collections.

XMU-MP-1 is an inhibitor of the Hippo pathway kinases MST1/2…[Read more]

This study is aimed to produce and characterize a novel gluten-free ingredient from oat through sprouting at 18 °C for 96 h. The nutritional and bioactive properties as well as key enzymatic activities were studied in sprouted oat powder and compared with those of oat grain powder (control). Sprouted oat powder was an excellent source of protein…[Read more]

Mammalian Rap1 is a part of the telomere binding complex named shelterin and is one of the most conserved telomeric proteins. With its essential requirement in lower species to its becoming necessary in higher species, it appears to have gained and lost several functions simultaneously evolving with telomeres. Mammalian Rap1 has been reported to…[Read more]

The elevated risk was still significant even when subjects were limited to those without any medical histories. The excess risk was observed not only for death occurring within the first 10 years of follow-up (multivariable HR, 2.05; 95% CI, 1.51-2.78) but also for that occurring in the longer follow-up period (multivariable HR, 1.48; 95% CI,…[Read more]

d isavuconazole prophylaxis per protocol. The rate of breakthrough candidemia was 3.1% and there were no invasive mold infections. Our data support the utility of isavuconazole for antifungal prophylaxis after HCT. Peripheral blood stem cells (PBSC) have been increasingly used for allogeneic hematopoietic cell transplantation compared to bone…[Read more]

Mucosal melanoma arising in the middle ear or eustachian tube is uncommon. We present a patient with hearing loss and otalgia found to have mucosal melanoma which occurred in the eustachian tube with extension into the middle ear cavity and external ear canal. Otologic clinics was consulted and biopsy of the mass located at the external canal was…[Read more]

The gut microbiota has been implicated in cancer and shown to modulate anticancer drug efficacy. Altered gut microbiota is associated with resistance to chemo drugs or immune checkpoint inhibitors (ICIs), whereas supplementation of distinct bacterial species restores responses to the anticancer drugs. Accumulating evidence has revealed the…[Read more]

l to understanding how change mechanisms activate within complex interventions to exert their impact on recipients. Intervention use and non-use were context-dependent, underscoring the need for further research to target eHealth innovations to those most likely to benefit.

Intervention-context interactions are central to understanding how…[Read more]

This study examined public comments on Twitter about coronavirus in the weeks after news stories across the globe on the coronavirus outbreak. A total of 600 tweets were assessed (N = 600) for sentiment, risks presented, attribution of blame, and outrage. A sample of 300 tweets was taken from Sunday, February 9, through Wednesday, February 19, 202…[Read more]

In addition, it is a state connected to several open problems in modern condensed-matter physics. Here we provide the means to stabilize it, opening the way to its experimental study. Moreover, we also provide a concrete experimental implementation of our model in currently available superconducting circuit arrays. We also investigate the…[Read more]

HBV VLs correlated well between both assays, across all genotypes (Pearson correlation coefficient r

 = 0.987). Six samples exceeded a 0.5  log difference between assays. Bland-Altman analysis demonstrated a mean of the difference of -0.107 log and a standard deviation of 0.271 log.

High correlation was observed between the Roche C…[Read more]